Although long considered highly reactive and unstable, accumulating evidence has indicated that stabilized sulfenic acids do exist and play a key redox regulatory role in a growing number of proteins (Boschi-Muller et al. 2008; Claiborne et al. 2001; Denu and Tanner 2002; Kaiserova et al. 2006; Shetty et al. 2007; Turell et al. 2008; Wood et al. 2003; Yeh et al. 1996).
By contrast, cleaved caspase-3 itself is relatively unstable, and evidence of its activation can disappear over time if monitored solely via cleaved caspase-3 abundance.
Regarding patients with cardiac disease but without acute myocardial infarction or unstable angina, evidence from the TRICC study suggests that this approach is safe in this group as well, provided euvolemia is maintained.
This region of the genome appears unstable as evidenced by loss of syntenic relationships between trypanosomes, abnormally sized intergenic regions and the presence of a short gene fragment (Tb11.01.3100) in assembly version 4 bearing no relationship to Hsp70, in contrast to earlier annotation.
This region, however, was quite unstable as evidenced by frequent CAA/CAG changes and small insertions and deletions.
While the ring itself appears to have remained stable as indicated by the consistent normal copy number for the control probe, the distal duplicated region at band 22q13 is unstable as evidenced by multiple cell lines ranging in CNVs from one to five suggesting a post-zygotic event involving a multiple-step process.
Additionally, the position of Platanista at the base of Odontoceti was unstable, with conflicting evidence coming from morphology, mtDNA, and nuclear DNA (reviewed in [ 10]).
Patients with psychotic disorders, active substance abuse or dependence, unstable medical condition, evidence of active liver disease, seizure disorder, unstable hypertension or cardiac disease, unstable asthma, and kidney disease as determined by the investigator were not included.
For example, a trauma patient with unstable vital signs, evidence of chest trauma and decreased breath sounds in one chest field may be needle decompressed in the pre-hospital system to treat a potential tension pneumothorax.
Our purpose is a) to strengthen the interpretation of the geographic patterns of risk that are "sustained" over time and b) to pinpoint "atypical" or "unstable" areas showing evidence of unusual variability in the time pattern of the risk.
