As in these disorders headache is frequently unspecific, highly variable in its clinical presentation and may occasionally even mimic primary headaches including migraine, diagnosis may in some cases be challenging.
Histologic and radiologic presentation in these patients is unspecific and variable, as recently demonstrated by Omote in a series of 44 patients with LD-CTD who underwent open lung biopsy [24]: the major histologic patterns were usual interstitial pneumonia (UIP) followed by NSIP, and UIP pattern was associated with worse prognosis.
The pathological changes are, unlike those in myosin storage disease, variable and unspecific.
Blood culture showed Candida sp. Abdominal ultrasonography revealed multiple unspecific hypoechoic areas of variable sizes in spleen, which might be either tumor or Candida-induced abscesses.
Another crucial variable is the unspecific stimulation of cells, which can prevent detection of low frequency T cell response and demands the use of autologous APC as well as critical selection of serum sources.
Most clinical variables are, however, unspecific which is why current research focuses on identifying clinically valuable biomarkers with high sensitivity and specificity.
Flu symptoms in birds are variable and can be unspecific.
LacZ staining has been considered specific when reproducing always the same pattern in at least 80% of positive embryos while has been considered unspecific when the expression was so variable that it was not possible to define its extension in a given territory.
Our approach to assessing treatment variables was on a relatively unspecific level and should be made more specific if intended for assessing resource consumption.
Instead, the clinical signs in female patients consist of unspecific mild to moderate mental retardation, combined with variable symptoms (autistic features, recurrent infections in early childhood, constipation, and late-onset neurological features).
