Our data strongly suggest that acetate exerts its proaging effects on yeast not only through rather unspecific events resulting from the primary toxic activity of extracellular acetate, but also through the Acs2p-mediated conversion of acetate to AcCoA.
However, an siRNA might trigger a number of potential unspecific events such as the degradation of partially complementary mRNA due to cross-hybridization, leading to unspecific RNAi, or the translational arrest due to a micro RNA-like effect where an siRNA hybridizes to a mRNA with one or few mismatches.
Besides the aforementioned FRN, which is sensitive to valence, previous research has identified a second valence-unspecific event-related potential (ERP) correlate of feedback processing called the "feedback-related positivity" or "feedback P3," which peaks approximately 300 400 ms following feedback and is sensitive to reward magnitude (Kamarajan et al., 2009; Yeung & Sanfey, 2004).
It can result from unspecific effect on these genes expression.
We included patients diagnosed with an acute first-time ischemic or unspecific stroke event according to the World Health Organization (WHO) criteria (ie, rapidly developing clinical symptoms and signs of focal or global loss of cerebral function lasting more than 24 hours or until death, with no apparent cause other than vascular origin).
This raises concerns that DAF-16 binding might not always correspond to gene regulatory activity, or suggests that the use of overexpressed DAF-16, the GFP tag, or GFP antibody may have increased the risk of identifying unspecific binding events.
It has also been shown that methylation confers additional stability to the genome by providing a more tightly packed chromatin, in particular along repetitive sequences and constitutive heterochromatic regions to avoid unspecific recombination events (Colot et al., 1996; Chen et al., 1998; Hashimshony et al., 2003).
These methods are rather unspecific and result in heterogeneous products.
In analogy to the ERP analysis, events with unspecific slow responses were excluded.
Pseudoconditioning may arise when a primary reinforcer sets a contextual background and provokes unspecific behavioral responses to any events within this context [ 61].
Other, non thromboembolic adverse events are rash, allergic reactions, lack of effect and unspecific symptoms such as pain, nausea or vomiting [ 20, 21].
