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The direct targeting of polyQ region might also provide unspecific action, especially if using high doses.
This mechanism has been invoked to explain an unspecific action on risk of all cancer (Mandal, 2005; Walker, 2007).
However, we would like to know whether the effects described above resulted from participation of recombinant BID in apoptosis and not from any unspecific action of TAT-BID fusion.
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To exclude unspecific actions of Ranolazine, we additionally used the Na+ channel blocker TTX (2 μmol/L) in combination with ATX-II, which also reversed the ATX-II effect on SR-Ca2+-leak and increased spark amplitude.
Although the translatability of our results is shown by the fact that inhibition of the respective kinases as well as of late INa successfully suppresses SR-Ca2+-leak in human AF, unspecific actions of ATX-II cannot be completely excluded.
Active substances with an unspecific inhibitory action against IV propagation--regardless of the viral subtype--would probably not lead to resistance, if such IVs do not evade inhibition by changes in their viral properties [ 17].
Antimicrobial peptides (AMPs) are promising candidates in the fight against antibiotic-resistant pathogens due to their low toxicity, broad range of activity and unspecific mechanism of action.
Agents working through unspecific modes of action are required to overcome this resistance such as octenidine dihydrochloride (OCT).
TMS possesses the advantage over any other therapy by being the least invasive procedure, but still with an unspecific target of action and outcome.
There were heartfelt, yet unspecific demands for immediate action, and calls for change from popular figures, including a tweet from the anti-corruption activist Arvind Kejriwal: "Aren't we all responsible for her death?
Furthermore, it is incompatible with an undesirable unspecific, promiscuous mode of action of the compound [63]; II) affinities against a panel of human pathogens of the paramyxovirus family as well as laboratory adapted and wild type influenza virus isolates were very similar throughout (average EC50 concentrations are ∼40 nM).
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