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However, the question remains unsolved whether these changes represent the cause or the consequence of RM.
In addition, it remains unsolved whether the dissipation indicators are influenced by meteorological conditions, how they are related with each other and which dissipation indicator has the largest discriminative power.
Problems are going unsolved, whether it is the border, the economy, the War on Terror, the cost of higher education, and others.
Importantly, it is currently unsolved whether the observed molecular responses reflect changes in muscle protein turnover and how they affect an apparent dysfunctional muscle remodeling machinery.
In this study, DNA methylation provided a strong signal to separate chronic epileptic rats from healthy controls, but it remained unsolved, whether the presence of spontaneous seizures (epilepsy) led to altered methylation, or if altered methylation influenced seizures.
Most clinically distinguishable malignant tumors are characterized by specific mutations, specific patterns of chromosomal rearrangements and a predominant mechanism of genetic instability but it remains unsolved whether modifications of cancer genomes can be explained solely by mutations and selection through the cancer microenvironment.
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It is still a major unsolved question whether paracetamol induces cell death of LSEC directly or whether the observed LSEC damage and the resulting hemorrhagic alterations are primarily a consequence of the release of cytotoxic compounds from dying hepatocytes.
However, it remains an unsolved question whether co-amplified genes represent silent passengers, or co-determinants of phenotype [ 23].
A critical question that remains unsolved is whether the LN compartment represents a primary site for the generation of initial autoimmune responses leading to RA. Incidentally, the occurrence of LN reactive hyperplasia before the onset of joint symptoms was already documented in historical studies performed in healthy subjects with unexplained lymphadenopathy [ 62].
An unsolved question is whether there can exist a complete set of mutually orthogonal Latin squares of order k if k is not a prime power.
Since there is no Picone-type identity for - Laplacian equations, it is an unsolved problem that whether the Sturmian comparison theorems for -Laplacian equations are valid or not.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com