The line was acquired in the 1920s, and was initially selected but was subsequently maintained unselected from 1965 to 2003.
The strength of this study is that the data are unselected from one large center covering the entire eastern part of Denmark.
The study sample was unselected from within the whole cohort population and its demographics are similar to the cohort as a whole.
Thus, cohorts recruited to investigate osteoporosis genetics focusing on a particular site, age, and sex are likely to have greater power to identify genes than studies of cohorts recruited unselected from the general population.
Associations between intracranial atherosclerosis and severity of plaques and sometimes tangles are reported from AD brain banks, but not from stroke banks, or from cases unselected for atherosclerosis or AD.
The samples were derived from patients unselected for a possible family history of cancer and diagnosed with mammary gland adenocarcinoma between 1988 and 1994 at the Oulu University Hospital.
Much work on the prevalence of BRCA1 and BRCA2 mutations among breast and ovarian cancer cases unselected for family history from populations with strong founder effects at both genes has been published in recent years.
Finally, Stacey and colleagues genotyped 311,524 SNPs in 2,183 cases and 12,877 controls from Iceland, again unselected for a family history of breast cancer [ 27].
To solve it, we first build a directed graph by creating two directed edges with the same weight for each edge of G and create a source vertex connecting to the vertices in V select with weight ω select and a sink vertex connected from the vertices in V unselect with weight ω unselect.
A further 1303 patients from the POSH cohort44 who were unselected for any survival differences and were independent of the stage-1 data set were used for replication analysis at stage-2 (Supplementary Table 1).
These affected sisters (the index patients) had recently been diagnosed with breast cancer and originated from a cohort of breast cancer patients who were unselected for age of breast cancer or family history.
