Systemic opioids for painful chemotherapy-induced oral mucositis in children often result in unsatisfactory pain relief and a high frequency of side effects.
Not only is unsatisfactory pain relief distressing for the patient, it also forms the basis of various postoperative complications and prolonged hospital stay and increases healthcare expenditures [ 8].
The clinical application of all forms of pharmacotherapy provides only partial reduction of pain, and frequently there is unsatisfactory pain relief with many unwanted side effects [ 4].
Given the high proportion of patients with unsatisfactory pain relief using CAM, general practitioners should gain knowledge about CAM and CAM providers should gain training in pain topics to improve communication and counsel patients.
Given the high proportion of patients with unsatisfactory pain relief using complementary and alternative medicine (CAM), general practitioners should gain knowledge about CAM and CAM providers should gain training in pain topics to improve communication and counsel patients.
This makes a relator action an uncertain, and hence an unsatisfactory, means of obtaining relief.
The more potent analgesic may subsequently be used if the patient's experience of pain relief with the previous basic analgesic was unsatisfactory.
Current analgesic regimens include paracetamol, nonsteroidal anti-inflammatory drugs, opioids, steroids and combinations thereof, but they are unsatisfactory for many patients, due either to inadequate pain relief and/or to intolerable side effects [ 7]; thus, a large unmet clinical need remains.
"…it is to be emphasized that the results of all known operative methods for the relief of joint ankylosis are at best most often unsatisfactory.
In conclusion it is to be emphasized that the results of all known operative methods for the relief of joint ankylosis are at best most often unsatisfactory.
After carefully reviewing the literature, he concluded: "…it is to be emphasized that the results of all known operative methods for the relief of joint ankylosis are at best most often unsatisfactory.
