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The remaining 40% unmapped reads could be ascribed to the following reasons: (1) some genetic polymorphisms may occur in the E. granulosus genome which interferes with Bowtie mapping; (2) unsatisfactory available genome data; some sequences are probably absent in the current draft genome of E. granulosus [ 16]; (3) miRNAs sequencing errors.
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Due to unsatisfactory outcomes of available chemotherapies, new therapeutic strategies for HCC are urgently needed.
There are still about one third of patients who have an unsatisfactory response to available treatments [ 11].
At this time, a very little, unsatisfactory information is available in literature on oxidative stress and hepatotoxicity of prallethrin in mammals.
So far, pathological findings based on examination of resected specimen are the most reliable information for prediction of clinical outcome, however, the predictive values of these variables remain unsatisfactory and not available for preoperative setting.
We could not confirm differences in ABC protein levels between control and hHSF1-overexpressing cells due to unsatisfactory specificities of available antibodies, which showed substantial cross-reactivity to other proteins.
Although killed-virus and modified-live PRRS vaccines are commercially available, the unsatisfactory efficacy and safety of current vaccines drives the impetus of developing novel PRRSV vaccines.
In the absence of any theoretical or empirical guidance, we regard our weighting scheme as the least unsatisfactory of the readily available alternatives.
This is probably due to the unsatisfactory efficacy of the available antiemetic drugs to prevent delayed emesis, a phenomenon which has been arbitrarily defined as vomiting and/or nausea beginning, or persisting for, more than 24 hours after chemotherapy administration [ 4].
However, because of the mixed source nature of the data, we found the available methods unsatisfactory when applied to histone marks, and therefore, as part of NucHunter, we also provide a method for estimating the average fragment length (described in Section 2.4).
One of the reasons a person may use diapers to manage their bedwetting (or other forms of incontinence) are: They may have tried various treatment options to resolve the problem without success or maybe they found available options unsatisfactory.
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