Sentence examples for unrestricted proliferation from inspiring English sources

Conversely, clinical researchers are developing telomerase inhibition therapies to treat tumors, which overcome the short-telomere barrier to unrestricted proliferation by over-expressing telomerase.

Two main hallmarks of cancer cells are unrestricted proliferation and suppressed cell death (Hanahan and Weinberg, 2011), raising the possibility of ATG7 as both an oncogene and a tumor suppressor.

Stem cells share a set of characteristics that indicate pluripotency or other stem cell related features like unrestricted proliferation and maintenance of an undifferentiated state.

In addition, anthrax toxins suppress the brain endothelial host response which could promote unrestricted proliferation and further dissemination of B. anthracis in the CNS.

Further studies using specific anthrax toxin-mutants, quantitative RT-PCR, ELISA and in vivo assays indicated that anthrax toxins actively suppress chemokine production and neutrophil recruitment during infection, allowing unrestricted proliferation and dissemination of the bacteria.

These proteins may provide new molecular targets to develop G2/M acting compounds inhibiting unrestricted proliferation.

Unrestricted cell proliferation during cancer is often associated with altered cell cycle and cell growth controls, and shape changes are associated with metastatic cells when they are escaping their tissue of origin and migrating elsewhere in the body.

The restriction point R has been recognized to be critical for growth control and thus also for the prevention of unrestricted cell proliferation, malignant transformation and tumourigenesis.

While we did observe neutrophil infiltration in the brains of B. anthracis Sterne infected mice at the time of death, we speculate that an initial reduction or delay in host neutrophilic response may promote acute unrestricted bacterial proliferation and further CNS dissemination ultimately responsible for the rapidly progressive deteriorating course associated with anthrax meningitis.

Unrestricted cellular proliferation and decreased sensitivity to apoptotic-inducing agents are typically associated with activation of these pro-survival pathways.

Subsequently EBV settles in resting B lymphocytes and renders infected B cells immortalized and unrestricted for proliferation [ 3].