Sentence examples for unrestrained formation from inspiring English sources

Disrupted roquin in sanroque mice leads to over-expression of ICOS and IL-21 in T cells, unrestrained formation of follicular helper T cells, autoantibody production and lupus phenotype [ 48].

The post-transcriptional repressor ROQUIN has previously been demonstrated to have a critical role in the negative regulation of Tfh cells as sanroque mice with a dominant negative ROQUIN mutation or T cell-specific deletion of ROQUIN and its paralogue ROQUIN2 leads to unrestrained formation of Tfh.

Loss of these activities during cancer development may be implicated in unrestrained growth and formation of viable colonies from detached, depolarised neoplastic cells during tumour progression.

Indeed, loss of nuclear WTPTEN has been correlated with unrestrained growth and tumor formation and progression.

The phosphatidyl-inositol 3 kinase (PI3K) signaling pathway has been reported to be involved in lymphoid development as impaired PI3K signaling results in immunodeficiency, while unrestrained signaling contributes to lymphoma formation and autoimmunity [6].

We used stable transfectants to investigate the effects of unrestrained Rac1 activity on contact-dependent growth arrest, adherens junction formation, and merlin intracellular localization and phosphorylation.

This leads to unrestrained proliferation of self-renewing neuroblast-like cells, and tumour formation ensues in the larval brain [ 27– 29].

The Great Depression put paid to the notion that individualism and unrestrained competition were natural and therefore good, and it stimulated the formation of labor unions and the institution of some features of state socialism such as national pensions for the aged.

Similarly, deficiency of Foxp3 in mice (scurfy mice) leads to unrestrained T-cell and humoral immune responses, which include spontaneous GC formation and Tfh cell expansion in the absence of immunisation or infection [ 42- 44].

These modifications prevent unrestrained recombination by regulating the stability and reversibility of critical recombination intermediates (DNA resection, Rad51/ssDNA formation, strand invasion and D-loop formation, and joint molecules resolution) through pro- and antirecombinogenic functions 66.

Contraction of unrestrained 3-DCM by fibroblastic cells is highly dependent on stress fibre formation, association of stress fibres with α-SMA, and linkage of cells into a cell network.