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Theodossiadis and colleagues treated three patients with exudative AMD unresponsive to ranibizumab with two injections of 2 mg of infliximab given 2 months apart [24].
Unlike Parkinson's disease, manganism is not associated with loss of smell and patients are typically unresponsive to treatment with L-DOPA.
Insulin therapy in patients with type 2 diabetes mellitus is generally reserved for patients unresponsive to management with diet, exercise, and oral antidiabetic drugs.
Labor was induced at 37 weeks or earlier in the presence of non-reassuring fetal testing, meconium, or severe maternal symptoms unresponsive to therapy with mature fetal lungs.
Although beta-cells appeared histologically normal, the pancreases were unresponsive to perfusion with stimulatory levels of glucose and arginine.
The findings suggest that most children who become unresponsive to monotherapy with zidovudine, as judged by clinical criteria, will have changes in in-vitro sensitivity to the drug.
Interestingly, the specific activity of superoxide dismutase was repressed by low to moderate concentrations of copper during exponential growth, and activity was unresponsive to perturbation with paraquot.
For example, lung and colorectal cancers that harbor mutations in the KRAS oncogene are unresponsive to treatment with anti-EGFR agents[4], and inactivating PTEN mutations (or protein loss) in glioblastomas predict resistance to erlotinib[5].
This is the reason why the infant in Case 2 was unresponsive to treatment with sulfonylureas.
The heterozygous ABCC8 mutation carriers were either responsive or unresponsive to therapy with diazoxide.
Immune thrombocytopenic purpura has been reported in a Gaucher patient unresponsive to treatment with corticosteroids (Lester et al, 1984).
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CEO of Professional Science Editing for Scientists @ prosciediting.com