Sentence examples for unresponsive to type from inspiring English sources

Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction.

To test the role of these cytokines we used IFNAR−/−CD8+ T cells, which are unresponsive to Type I IFNs, and IL-6−/− host and donor mice.

However, 2fTGH cells are unresponsive to type III interferon (Zhou et al., 2007).

In order to delineate why these behavioural and metabolic responses in the CNS are different in animals unresponsive to type I IFN, we first assessed the cytokine profile in blood and brain, revealing some striking differences.

The unique feature of Ba/F3 cells (pro-B lymphocyte cell line) is the lack of membrane gp130 molecules, which makes them unresponsive to IL-6 type cytokines.

Insulin replacement therapy has been a mainstay of treatment for patients with type 1 diabetes and a third-line alternative in patients with type 2 disease unresponsive to diet/exercise and oral antidiabetic drugs.

In contrast, EBV-negative, monomorphic types are unresponsive to the reduction of immunosuppression and have a poorer prognosis.

Mutant RGC axons in the tectal neuropil remained unresponsive to visual stimulation, whereas wild-type axons were robustly activated.

Low levels of SMN protein may disrupt the cytoskeletal protein interactions and regulating pathways, which could be a possible explanation of why, in our study, the SMN knockdown cells were unresponsive to curcumin but the wild-type PC12 cells were not.

Treat Type 1 reactions with systemic corticosteroid, such as prednisone 40-60 mg (adults) or 1 mg/kg (child) per day initially, then maintain at a lower dose of 10-15 mg per day for a few months.[5] For Type 1 reactions unresponsive to prednisone, consider applying tacrolimus 0.1% ointment to affected skin, which has documented efficacy.[9].

Many advanced cancer patients receive EOL chemotherapy, even those with cancer types known to be unresponsive to chemotherapy [ 9].