In the long term, elevated levels of insulin may cause the body to become relatively unresponsive to the effects of insulin, which has the potential to lead to type 2 diabetes in time.
Expression of the IFNLR1 is cell-type specific, with high expression in epithelial cells and little or no expression in endothelial and fibroblast cells, rendering the latter unresponsive to the effects of IFNλ [14], [15].
This is supported by the observation that while the performance of laboratory animals in the conefield task can be altered by cognition impairers [ 18], performance in other spatial learning and memory tasks, such as the Morris water escape task, is unresponsive to the effects of cognition impairers once the task has been learned to an asymptotic level [ 31].
And yet the National Cancer Institute has been unresponsive to the issue of palliative care.
The fact that fibroblasts were completely unresponsive to the cytostatic effect of the SCD inhibitor suggests that non-cancer cells have a smaller requirement for endogenously produced MUFA than cancer cells.
Prostate cancer cells are only modestly responsive or even unresponsive to the cytotoxic effects of chemotherapeutic agents or radiotherapy.
During tumour progression, transformed cells become unresponsive to the tumour-suppressive effects of TGF- β and respond with tumour-promoting effects by undergoing changes in morphology leading to increasing cell mobility, invasion, and metastasis (Xu et al, 2009; De Craene and Berx, 2013).
First, DAT knockout animals are unresponsive to the locomotor stimulating effects of both cocaine and AMPH and, in fact, exhibit reductions in locomotor activity when administered stimulants, through elevations in serotonin levels.
Strikingly, Lyn deficiency rendered BMDMs completely unresponsive to the signal-potentiating effects of priming; Lyn−/−CskAS BMDMs primed with IFN-γ failed to signal through Erk after 3-IB-PP1 treatment even though they express normal macrophage surfaces markers.
Adenomas were unresponsive to the DNA synthesis-enhancing effect of PB, maintaining a level of 20-25%.
