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However, other than a small increase in HDL cholesterol from baseline to follow-up in both groups, these variables were unresponsive to either of the treatments.
Thyroid hormones that regulate resting metabolic rate were unresponsive to either of the treatments, with systemic concentrations of triiodothyronine (free-T3) and thyroxine (free-T4) closely matched between treatments at baseline and follow-up (Table 2 ).
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Five micromolar flecainide was also tested; however, over a third of hearts (10 of 27) then became unresponsive to stimulation during either or both regular pacing (particularly at the higher frequencies) and PES.
A group of genes displayed differential expression between the cell lines, but were either unresponsive to GF treatment or responded similarly in the two cell lines (Table 1).
Tissues that are completely unresponsive to mTORC2 inhibition under either experimental condition include thymus, kidney, and stomach (Figs 6C, S3 and S4).
We concluded that under the condition of our experiments, the cells were either unresponsive to PGE2, or the levels of PGE2 produced were too low to affect MMP and TIMP production.
Patients were eligible if they had a histologically or cytologically confirmed nonhaematologic malignancy that was either unresponsive to standard therapies or for which there was no known effective therapy.
Unfortunately, a large proportion of especially elderly patients are either unresponsive to or intolerant of the use of currently available medications such as xanthine oxidase inhibitors and NSAIDs because of the presence of significant comorbidities such as renal failure, cardiovascular disease, or being at risk for gastrointestinal bleeding.
Fifteen patients (15.0%) were unresponsive to therapy and were given either systemic corticosteroids alone or in combination with immunosuppressive drugs.
So far, three different phase I trials have been performed in NB patients unresponsive to conventional treatments, by employing either autologous or allogeneic NB tumour cells engineered to produce IL-2, alone or in combination with lymphotactin (Brenner et al, 2000; Rousseau et al, 2003; Bowman et al, 2003).
The heterozygous ABCC8 mutation carriers were either responsive or unresponsive to therapy with diazoxide.
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