Mutations in UVSSA were recently identified to cause UVSS, a previously unresolved TC-NER deficiency disorder with rather mild clinical manifestations as compared to CS. UVSSA and its interaction partner USP7 were identified as new factors involved in TC-NER repair efficiency and cell survival after UV damage.
In stark contrast, video evidence of shameful behavior, intellectual deficiencies, countless unresolved lawsuits, multiple business bankruptcies, child-rape allegations and threats, murky international financial ties, and a host of concerns demonstrate that Trump's intellectual and moral bankruptcies threaten America with a woefully unfit administration.
Elucidation of the precise mechanisms for unregulated B-cell proliferation as a result of AID deficiency is an important unresolved issue.
We find that Batf3 deficiency results in exaggerated and unresolved pathology, with skewed T-cell differentiation in the dLNs and an impaired Th1-cell effector response at the infection site, leading to defective control of the parasite.
Despite several decades of research, the causes of such functional deficiencies in human spermatozoa remain largely unresolved.
With such diverse roles for dysferlin, the mechanism through which dysferlin deficiency results in muscle pathology is unresolved.
infection with L. major in the ear pinnae [ 1], we show that Batf3 deficiency leads to an exacerbated and unresolved pathology, with a 1000-fold increase in local parasite load.
Based on a review of the deficiencies of existing observational approaches and of unresolved research questions and hypotheses, we discuss the fundamental criteria that shaped the design of our platform.
In light of the potentially unresolved question of carbon or P limitations under P deficiency it would be desirable to model the effect of alternative root-to-shoot distribution patterns of P and carbon on the growth and nutrient acquisition of rice under various levels of P deficiency.
However, the role of PTP1B in adipocytes is unresolved with studies demonstrating detrimental or beneficial effects of adipose PTP1B deficiency on body mass and insulin sensitivity [ 25, 26].
