3– 7 However, in many cases the genetic defect remains unresolved.
The BRCA1 and BRCA2 genes are the major causes of hereditary breast and ovarian cancer, but the underlying genetic defect remains unresolved in the majority of the families with familial or hereditary breast cancer [ 1, 2].
While a direct role of Nde1 in mitotic spindle organization remains plausible, we also believe that the skewed mitosis previously observed in Nde1−/− neural progenitors may, at least in part, originate from unresolved centromeric and pericentromeric structural defects arising during S phase.
However, when intracellular stresses remain unresolved, prolonged autophagy upregulation progresses into autophagy defect [ 139; 139].
The exact cause of T cell defects in Bcl11b-deficient mice thus remained unresolved.
To date, there is no cure for CNM and many unresolved questions remain, including the mechanisms leading to skeletal muscle defects in patients.
The reconstruction of soft tissue defects following extensive deep burns or tumor resections remains an unresolved problem in plastic and reconstructive surgery since adequate implant materials are still not available.
As such, the question of whether or not polarization defects of Pod mutants are secondary to osmotic sensitivity remains unresolved.
An important unresolved question is whether p107 and p130 compensate or exacerbate the differentiation defect of Rb-deficient myoblasts.
This defect was greatly reduced by deletion of RAD51, suggesting that unresolved HR intermediates cause the observed mis-segregation in mus81 yen1 cells.
