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Combined, this evidence suggests the frequent occurrence of previously unreported interactions between PAX1 and PAX5 promoter methylation and exonic mutations in NOTCH1 and TP53 in HNSCC.
This evidence suggests a frequent occurrence of previously unreported interactions between PAX1 and PAX5 promoter methylation and exonic mutations in NOTCH1 and TP53 in HNSCC, respectively (Table S8B).
Coexpression in several cases was consistent with known interactions (GATA2-Tal1 or GATA1-GFI1B) alsoalsuggestedted as yet unreported interactions between known key regulators (GATA3-GFI1; GATA3-GFI1).
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In the course of the discussions he noted in passing his hitherto unreported interaction with President Kennedy at the height of the Cuban missile crisis.
Biochemical profiling also identified previously unreported chemical target interactions that may suggest potential modes of action or off-target effects.
In addition to previously reported associated lesions, this large cohort of patients allows the statistical power to reveal other significant and previously unreported co-occurrence interactions, including the co-occurrence of BIRC3 abnormalities with +12 and NOTCH1 mutations and the co-occurrence of 13q14 deletion and BIRC3 deletion.
BIND was queried for previously unreported homeodomain protein protein interactions in parallel with the aforementioned PubMed literature searches, using general (e.g. 'homeobox OR homeodomain AND interaction') to more specific (e.g. 'homeobox OR homeodomain AND interaction_object_type = protein AND NOT = DNA') search criteria.
These include, for example, the elucidation of protein protein relations in terms of ligand or cavity topological similarity via quantitative measures and the prediction of unreported potential ligand-target interactions by detecting potentially cross-binding ligands.
This study demonstrated unidirectional apparent prey predator facilitation through TMIIs, an unreported type of interspecific interaction.
Taken together, these data demonstrate that RIM1α SUMOylation has a previously unreported role in PDZ interaction-mediated CaV2.1 clustering.
We found previously unreported complex behaviors including the observation that interactions between fibronectin and integrin α5β1 generates biphasic tissue cohesion profiles.
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