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In our previous work [ 3], we have shown that using the topology of the PPI network to weight interactions, remove unreliable interactions, and posit new interactions improves the performance of several complex discovery algorithms.
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This result indicated these two algorithms perform better when unreliable functional interactions were eliminated.
However, networks with very high densities such as SharedGOTermComNet and SharedPPIComNet, may contain unreliable functional interactions that can reduce the performance of the methods.
This can be a confounding factor potentially leading to under- or over-estimated drug levels, toxicity, side effect profiles, drug-herb-vitamin interactions and unreliable clinical trial data [ 10].
Most casual observations of carer-child interaction are unreliable as indicators of attachment relationships.
Tesfamicael Gerahtu, an Eritrean diplomat, said: "My delegation is dismayed at the protracted reliance on unreliable, unproven and sensational information and interactions.
Tesfamicael Gerahtu, an Eritrean diplomat, said his delegation was dismayed at "the protracted reliance on unreliable, unproven and sensational information and interactions", adding that "preconceived ideas and conclusions" about Eritrea had become rampant.
Commercially available implantable needle-type glucose sensors for diabetes management are robust analytically but can be unreliable clinically primarily due to tissue sensor interactions.
These interaction results might be unreliable resulting from the small numbers in the various categories.
This method is not only time consuming, but also can't describe the interactions between different factors, leading to unreliable results.
Although individual edge weights may be unreliable, deviations will average out when many weighted interactions are combined (Nepusz et al., 2012).
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CEO of Professional Science Editing for Scientists @ prosciediting.com