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In conclusion, in standard neoadjuvant therapy, clinical response is an unreliable endpoint for outcome.
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First, the LVEF as a primary endpoint is unreliable and inappropriate, because heart failure with preserved ejection fraction exists.4 Second, among the 7 patients, 5 were classified as "responders" to this therapy.
Shorter clinical trials are cheaper for industry but frequently rely on measures of effect called surrogate endpoints that can be unreliable predictors of ultimate outcome and do not necessarily correlate with benefits for patients.
Some of the cytological endpoints are found to be unreliable.
The exclusion of two trials with unreliable PFS from our meta-analysis casts further doubts on the usefulness of this endpoint in advanced NSCLC, at least as measured a decade ago.
It's not an endpoint".
SPARQL endpoint.
But is there an endpoint?
and unreliable.
It is also unreliable.
But polls are unreliable.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com