However, no inverse association between fecundity and longevity is evident in both bdelloid species; lifespan appears unrelated to fecundity in A.r., and is directly, and not inversely, associated in M.q.
The effect of smg-1 inactivation on lifespan appears to be unrelated to its NMD function, but requires the p53 tumour suppressor orthologue cep-1.
Interestingly the role of SMG-1 in lifespan appears to be unrelated to its function in NMD, but requires the p53 C. elegans ortholog, cep-1, daf-18, and daf-16.
Elimination of all germ cells by laser ablation results in lifespan extension (Hsin and Kenyon 1999), which appears to be unrelated to the production of oocytes or sperm, whereas mutants that result in germ cell overproliferation cause lifespan shortening (Arantes-Oliveira et al., 2002).
Overall, although it could be related to extrinsic factors like predation, parasites or infectious diseases unrelated to ageing, there is a clear trend for longer lifespans at lower ambient temperatures in wild species of ectotherms (Munch and Salinas 2009).
Maximum lifespan often indicates effects on mechanisms of aging more reliably than mean or median lifespan, as the latter may be altered by early deaths unrelated to aging.
Since the time course of TB infection is of the same order as the human lifespan and the majority of infected individuals eventually die of causes unrelated to TB, demographic effects are likely to be important for predictions about control interventions.
If metformin both prevents cancer and extends lifespan in cancer-prone (e.g. neu-N transgenic mouse model of mammary cancer) strains of rodents, metformin's ability to prolong lifespan without affecting cancer in non-cancer-prone strain of rodents (e. g. SHR) may suggest that metformin can prolong life (and delay aging) by mechanisms unrelated to its ability to suppress cancer.
In this analysis we wanted to probe whether mdl-1 tm311 mdl-1 tm311ifeshortensaccelifespan aging or whether it could act by acceleratingening effect unrelagingtoraging.
(It is unrelated to Starwood Hotels and Resorts).
