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The crystallographic analysis has unveiled the structural background of their actions, explaining how antibiotics of unrelated structures and binding modes and sites can employ similar mechanism of action.
Many of the new shapes are tried out on computer first and a program called Cordin, invented by Pieter Huybers at the University of Delft, applies Thompsonesque transformations to architectural designs and shows how what appear to be unrelated structures can be derived from each other.
This removes all the bones and unrelated structures that fall into the 440 3071 HU range.
However, ligands of the same pharmacology with unrelated structures are still among the top hits.
The metamaterial structures are designed thanks to the powerful ability of transformation optics to establish relationships between seemingly unrelated structures, particularly between complicated and simpler structures.
Since this is based on the similarity of adjacent conformations, completely unrelated structures can exist in the same cluster [26].
Similar(44)
Elongation factor Tu (EF-Tu), the carrier of aa-tRNA to the mRNA-programmed ribosome, is the target of four families of antibiotics of unrelated structure, of which the action is supported by two basic mechanisms.
However, an accurate detection of similarity between the protein complexes containing subunits of unrelated structure remains an open problem.
All experimental intensities were replaced with an actual intensity value that was measured by X-ray crystallography of an unrelated structure (Calmodulin PDB ID 3SUI [ Lau et al., 2012 ]).
Each candidate family, for which the relationship to known GIY-YIG sequences was confirmed by reciprocal searches, was also analyzed by fold-recognition (FR) methods to evaluate its compatibility with the known GIY-YIG structures (or detect cases, where some other, unrelated structure appeared to be a better template).
Although their functions are unrelated, the structures involved in excretion and reproduction are morphologically associated and often use common ducts.
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