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The latter is probably of independent origin and unrelated function.
Moonlighting of a protein describes the performance of an additional, unrelated function apart from its established one.
However, it is more likely to have an unrelated function due to the non-overlapping intron/exon structure.
Further, it might be possible that these ORFans may exhibit some unrelated function while their 3D structures have converged to a similar fold.
However, we find that loss of ALKBH3 does not directly affect expression of ALKBH3 occupied genes, suggesting a transcription unrelated function of ALKBH3.
Because CG30461 shows no significant homology to any of the STE24 paralogs, and it has been classified as an unrelated function.
Similar(47)
There appears to be no functional association with such extreme divergence because genes with unrelated functions (ribosomal, electron transport, and protein transport/maturation genes) all exhibit extreme divergences.
CheY, Spo0F, and NtrC have unrelated functions and low sequence homology but share an identical topology.
Colleagues of Ben-Ze'ev had examined the effect of turning off b-catenin on other, unrelated functions within cells.
Despite their relatively close relationship and the fact that both can bind calcium and affect mineralization, their functions are not redundant and they also have other unrelated functions.
This is evident from equation (3) in which (q(x)) is the result of combining two unrelated functions (b(x)) and (c(x)).
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