Sentence examples for unregulated inflammation from inspiring English sources

The consequences of unregulated inflammation are associated with the development of pathologic fibrosis such as that seen in SSc [ 15].

However, unregulated inflammation can lead to disease [ 24], therefore a balanced inflammatory immune response is key to sufficient bacterial clearance and the restoration of an endometrial environment capable of supporting a new pregnancy [ 25].

We have previously published an observation to suggest that excessive TLR4 receptors are expressed on the surface of fetal enterocytes (H4) cells and these receptors are further unregulated with inflammation [16].

NGF has been most studied with respect to inflammatory hyperalgesia as its production is unregulated by inflammation in macrophages, fibroblasts and Schwann cells.

Hepatocarcinogenesis is a complex process involving chronic liver injury, inflammation, unregulated wound healing, subsequent fibrosis and carcinogenesis.

In postmenopausal women, estrogen reduction causes deleterious skin changes, resulting in delayed cutaneous healing that is associated with increased inflammation, reduced matrix deposition, and unregulated protease activity [ 2].

Necrosis has long been viewed as an unregulated form of cell demise that promotes inflammation and tissue damage, whereas emerging evidence indicates that some forms of necrosis are programmed.

The ability to differentiate between host and viral RNA is essential, as aberrant activation of RIG-I would result in unregulated signaling that could lead to auto-inflammation and other innate immune disorders.

Current doctrine holds that at sites of inflammation, cytokines, chemokines and matrix degrading enzymes are released in a persistent unregulated manner predominantly by cells of the innate immune system serving to enhance angiogenesis, invasiveness and promote survival of pre-malignant and neoplastic cells.

During sepsis, unregulated inflammatory cytokines, including the inflammatory cytokine TNF-α, can result in organ failure and severe pathologic inflammation [ 9].

It is clear that alterations in normal signal transduction pathways that impact barrier homeostasis (proliferation/apoptosis/necroptosis) result in unregulated passage of luminal bacteria across the epithelium and subsequent aberrant activation of the mucosal immune system, leading to inflammation [ 40, 56, 57].