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In the multivariate analyses, we were able to adjust for a large number of potential confounding factors, but the possibility of residual confounding by an unrecognized factor cannot be ruled out.
The higher reproductive success for birds within noisy habitats may be a previously unrecognized factor contributing to the success of urban-adapted species and the loss of birds less tolerant of noise.
Sleep phase delay is an important and generally unrecognized factor in sleepiness and needs to be recognized as a normal and frequent occurrence in adolescence.
We assume that the small size of the sample, fortuity and probably some unrecognized factor other than antibiotic therapy played a role in the different mortality.
Intratumoral acidosis is a previously unrecognized factor contributing to loss of prolactin-induced Nuc-pYStat5 human breast cancer, and implicates acidosis-associated prolactin resistance as a novel mechanism by which breast cancer cells escape pro-differentiation and invasion-suppressive effects of prolactin.
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Nevertheless, the possibility of residual confounding by unrecognized factors cannot be wholly excluded.
Also, the possibility of residual confounding by unrecognized factors cannot be ruled out.
But in our study, nitrofurantoin showed only 57.3% sensitivity; the reason for this low sensitivity and high resistance to almost all antimicrobials in the study area may indicate difference in antimicrobial usage, infection control practices and other unrecognized factors including genetic propensity of these strains to accumulate mutations conferring MDR phenotypes.
However the issue of residual confounding by other unrecognized factors must still be considered.
However, other as yet unrecognized factors may also have played a role.
Other unrecognized factors might affect the treatment choice but were not included in our analysis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com