Our study reports a previously unrecognized epidermal expression of PDX1 and adds further evidence for a pivotal role of Notch1 but not Notch2 as a tumor suppressor in the skin, which may be particularly interesting in the light of new therapeutic approaches targeting single Notch receptors [45], [46].
Through cDNA tag profiling, we describe previously unrecognized gene expression complexity in MA glands of the Western black widow.
This approach provides more accurate information regarding the rate of protein synthesis, and identifies some mosquito factors that might have gone unrecognized because expression of these proteins is regulated mainly at the translational level rather than at the transcriptional level after mosquitoes ingest a Plasmodium-infected blood meal.
In conclusion, Hfe deficiency caused a previously unrecognized increase in gene expression of hepatic acute phase proteins and duodenal digestive enzymes.
Other investigators noted that ICP4 produced a modest decrease in ICP0 mRNA levels in the context of ICP0+ viruses [37], but ICP4's full potential to silence ICP0 gene expression went unrecognized.
These findings provide new insights into the role of the ETS transcriptional network in prostate tumorigenesis and uncover previously unrecognized links between aberrant expression of ETS factors, deregulation of epigenetic effectors and silencing of tumor suppressor genes.
These comparisons revealed previously unrecognized relationships between gene expression, alternative splicing, and exon methylation.
Recently, Takahashi et al. investigated a previously unrecognized protein, FEAT (faint expression in normal tissues, aberrant overexpression in tumors), and identified it as a novel, prominent promoter of tumorigenesis [ 3].
While diabetes was certainly not the epidemic we now face, Bell stated in his commentary that "Hyaline islets are an expression of unrecognized or potential diabetes"—a clear recognition of the link of these deposits to diabetes and the problem of undiagnosed diabetes.
While in this study rapamycin was administered only to the mutant cells, we observed a previously unrecognized downregulation of V-ATPase expression by rapamycin (Supplementary Figure S2).
