Before examining the construct validity for SciComm productivity, we observed that the distribution of the productivity data was not normal, and that the data were positively skewed (i.e., the bulk of the data were low values with a few outliers reflecting unreasonably high values).
However, animal threshold models applied to cross-sectional binary data (one observation per individual) have been shown to give a biased estimation of genetic parameters, particularly in the presence of numerous fixed effect classes [ 2- 4], and genetic variance has been shown to "blow up" to unreasonably high values when using Markov chain Monte Carlo methods (e.g., the Gibbs sampler).
Using the results of the FVA analysis (step 2), reactions that carry unreasonably high flux values (for case of YP v ― i ≥ 100 ) are eliminated, since these reactions could cause numerical problems when solving the GX-FBA objective function and likely take part in type III extreme pathways [ 49].
Although values of adhesion are unreasonably high, cracking of the substrate occurred, violating the critical assumption of negligible substrate compliance.
However, the values simulated are not unreasonably high.
In addition, setting the value at, say, 0.3 seems unreasonably high, as this is consistently well into the range of frailty, however, defined (including by an increased hazard) so would be insensitive.
Some traders took advantage of this subjectivity to set unreasonably high curves, and later to change those curves to establish even higher values, which they could report as profits immediately, a former manager on the trading desk said.
The theory gained prominence at the height of the market boom in the late 1990's, when researchers noted that the overall value of Tobin's Q in the market looked unreasonably high relative to historical norms.
"I still thought prices were unreasonably high".
