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He and the rest of the Cochrane team asked Roche for the full, unpublished trials data.
But there are problems in analyzing published and unpublished trials in a "meta-trial".
"Why are we still referring to these as unpublished trials?
To assess the value of searching for unpublished data by exploring the extent to which Cochrane reviews include unpublished data and by evaluating the quality of unpublished trials.
We searched MEDLINE, Embase, and CENTRAL for published trials from 2007 to 2012 and ClinicalTrials.gov for unpublished trials registered since 2011.
A systematic literature search of the years from 1980 to 2009 revealed 27 large phase III trials in TBI; we were aware of a further 6 unpublished trials.
Unpublished trials were searched electronically using ClinicalTrials.gov (www.clinicaltrials.gov), the National Research Register (www.controlled-trials.com), and ProQuest Dissertation and Thesis database (http://pqdtopen.proquest.com).
What we know from clinical experience -- that antidepressants work best with people who have severe depression -- was actually borne out by the unpublished trials Dr. Kirsch studied.
Published in the journal Family Practice in September 2012, the team's analysis combines data from the eight unpublished trials with data from three published ones and gives a far less obstructed view of Tamiflu's effects.
Dr. Kirsch then went on to study data from published and unpublished antidepressant drug trials and found that antidepressants performed about as well as placebo in many of the unpublished trials.
Key: * Unpublished trials.
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