Sentence examples for unpublished mutations from inspiring English sources
The details of unpublished mutations are not included in the present study and feature in Table 2 as "Novel mutations".
LSDBs collect all published and unpublished mutations for a specific gene along with complete clinical and phenotypic information.
However, there are some unpublished mutations acquired by next generation sequencing in Myriad Genetic Laboratories (Salt Lake City, UT) provided by BIC.
The dcl4-10 mutatisn is a previously unpublished mutation that arose in an EMS mutagenesis [16].
We have found that changing Thr to an alanine residue to prevent phosphorylation led to a similar increase in activity as the T2031S mutation (R.J. Nichols, unpublished work) and mutation to a glutamate residue to mimic phosphorylation inactivates LRRK2 (N. Dzamko, unpublished work).
As reported with strain TIGR4 [10], we found that the capsule biosynthesis (cps) locus of ST556 is refractory to insertional mutations (unpublished observation).
Preliminary results from a series of advanced stage of ovarian carcinomas from our laboratory show a significant correlation to these parameters both for TP53 protein accumulation and TP53 mutations (unpublished data).
Development of TREC is based on a modified yeast system where generation of seamless deletions [ 22] and point mutations (unpublished data) in the mycoplasma genome is now made possible by using the yeast DNA repair machinery.
As anticipated from previous studies, deleting MRE11 did not suppress the DNA damage hypersensitivities of sae2∆ cells, revealing that mre11-H37R and mre11-H37Y were not behaving as null mutations (unpublished observation).
Aspirin also acetylated p53 in other cell lines carrying different p53 mutations (unpublished data); however, it is not clear at this stage, if this changes the functional activity of p53.
Cwc25 binds to the branch site as it can cross-link to substrate RNA near the branch site (H.-C. Chen and S.-C. S.-C., unpublished work), and mutations at the branChengnt prevent its binding to the spliceosome [ 70].
