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Besides its computational cost and need for large data storage made this model unpromising, unless comparison of test cases with their k neighbours is considered important for comparative diagnosis.
SiS exploits the use of template network in two ways: (i) it limits the search to the template network rather than every network in the data set and (ii) it prunes a massive number of unpromising solutions by using lower and upper bound values to the sum of the weights of all the edges in the tentative solution subnetworks.
The recent literature debate about cancer biomarkers has focused attention to several crucial aspects and caveats: a) complexity and underestimation of the problem, b) missing data on cancer biology knowledge, c) funding limitations, d) inappropriate clinical setting, e) unpromising discovery and scarce/neglected validation, f) pre-analytical and methodological shortcomings, etc. [ 18- 20].
Quinlan and Cameron-Jones [ 15] argue that these rather unpromising results are due to oversearching the hypothesis space, resulting in an overfit of the training data.
Yet despite this unpromising backdrop, the manufacturing PMI has posted one of its strongest monthly increases in a run of data going back the best part of a quarter of a century.
The wFReDoW results show that when P-SaMI data pattern starts the analyses of the FFR model with 30% of docked snapshots, the number of unpromising snapshots discarded is higher.
The infant is unpromising.
The portents are unpromising.
The trajectory was unpromising.
These were unpromising.
Although data strongly support ERCP for treating anastomotic strictures, the little information available for the role of ERCP in the treatment of nonanastomotic strictures (NAS) has been unpromising.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com