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The result is a varied, unpredictable sample of the band's versatility.
Limitations include unpredictable sample representation, development of compromise position rather than consensus, and absence of blinding in validation exercise.
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Two error rate cutoffs are fixed to identify the unpredictable samples for the following two different targets.
In other words, the unpredictable samples in the endpoint F are also difficult to be predicted in the endpoint G and visa versa.
Third, for endpoint F, all unpredictable samples (error rate larger than 0.97) were falsely predicted as OS survivors by almost all the predictive models but presented less that 730 days of overall survival.
One sided Wilcoxon rank-sum test was also performed in the same software to detect the significance of the difference between OS (overall survival milestone outcome) times and EFS (event-free survival milestone outcome) times in the unpredictable samples.
Along with the redefined cutoff, the first principle component scores of six out of the nine unpredictable samples are less than the posterior mean of the score of the OS negative samples, and almost beyond the visibly narrowed dense region of the OS negative samples.
Second, the difference between OS times and EFS times is significantly smaller in the unpredictable samples than that of other samples by the one sided Wilcoxon rank-sum test (p value < 0.05), which indicates that it is difficult to predict those samples that have suffered from severer disease with quick deterioration.
Next, we adopted the PCA change point method (see methods) to carry out the analysis for those unpredictable samples (see methods) and try to get a deeper insight into the phenomenon of the OS positive uniformly misprediction and the effect of the intuitionistic understandable solution mentioned above.
For the 730 days cutoff given by the MAQC-II project, the first principle component scores of eight out of the nine unpredictable samples are larger than the posterior mean of the scores of the OS positive samples, and fall into the center region of the first component score of the OS negative samples, which is a visible evidence for us to understand the unpredictability.
This indicates that the redefined cutoff makes it possible to improve the true positive rate for these unpredictable positive samples.
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