Mark Fineman, San Diego, California, from Elcelyx Therapeutics sympathized with the "underappreciated" difficulty of the FDA task but described what he saw as a regulatory trend in the U.S. to have higher scrutiny of safety in development and postmarketing, leading to longer and unpredictable review times, more review cycles, and late-stage project withdrawals.
Hence, the cases decided are fact-specific and depend upon each court's interpretation of the relevant statute, making success of the judicial review somewhat unpredictable.
Thank you for submitting your work entitled "Normative evidence accumulation in unpredictable environments" for peer review at eLife.
As a consequence, the impact of missing reviews is unpredictable and probably limited on our meta-epidemiological study.
On the subject of reviews, British critic Mark Lawson notes the tendency for Ellis' reviews to be "unpredictable"; he cited the irony of favour amongst right-wing critics, and the extent to which the liberal media attack his work.
A team of knowledgeable writers review a superb left-field, less mainstream, unpredictable selection of music, art, literature, theatre and dance events – and the occasional picnic too.
"For the small number whose applications survive to receive full review," Posselt continues, "judgments are thus holistic, complex, and unpredictable".
The race for best actress in a play is far more unpredictable, with all five nominees earning some of the best reviews of the season.
"His enthusiasm is boundless, his imagination unpredictable and diverting," the novelist John Deck wrote in The New York Times Book Review.
Because all human subject research was reviewed by a single National Ethics Committee, the process was slow and unpredictable.
In his review for The Times, A. O. Scott called Mr. Brand's performance "brilliantly unpredictable".
