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It is unlikely any technique can ever account for this given the constraints of working with small DNA fragments, incomplete databases and in some instances, the unpredictable reactivity of reagents with prey sequences.
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Early work was limited by the fact that B alloantisera are rarely haplotype-specific and unpredictable cross-reactivity made it difficult to identify MHC- B haplotypes across breeds and lines.
One outstanding question in T cell biology is therefore whether T cell cross-reactivity is mostly a stochastic phenomenon induced by unpredictable structural constraints or, whether we can predict which peptides should be cross-reactive.
In this study IgM-class reactivities were detectable but in a very unpredictable fashion while IgG-class antibodies did not recognize peptides even methylated ones in any of the patient groups.
However, subtle, sex-specific effects of prenatal cocaine exposure were seen on measures that indicate impairments in sustained attention and "readiness", as well as altered reactivity to task-related stressors such as waiting for long and unpredictable delays.
Substituting the mouse C regions with human C regions in chAbs was a major advance in reducing the immunogenicity of mouse mAbs but our results show that this approach can have unpredictable effects on the thermodynamics of Ag-Ab complexes and the self-reactivity of chAbs.
"Unpredictable, too".
"Instant reactivity always favours the familiar.
Completely unpredictable.
"Very unpredictable.
But this surface reactivity may come at a price.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com