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Such random integration may result in alteration of gene expression or gene disruption by unpredictable position effects.
Recently, this can be achieved by integrating of exogenous DNA randomly into genome of this pathogen, but ectopic integration may result in alteration of gene expression or gene disruption due to unpredictable position effects and/or disruption of protein-coding regions.
Multiple studies are on the way to determine the underlying mutations of orphan PARK loci; however, the length of putative regulatory regions of most gene, their unpredictable position, and the common presence of SNPs have thus far restricted such studies to nucleotide variation in the coding region and in 5′ and 3′ UTR.
Similar(57)
Balancing these twin experiences, President Clinton embraced a series of unpredictable positions that in turn angered both conservatives and the leaders of traditionally liberal civil rights groups.
"We found that some regions responding very similarly to the movie can relocate to odd unpredictable positions," says senior author Wim Vanduffel of the University of Leuven.
In contrast, when the target appeared at unpredictable positions in the visual field (random context), localization judgments were at least drastically reduced.
And the unpredictable attitude.
Have an unpredictable attitude.
He is also seen as unpredictable, changing positions for reasons of political expediency.
But this technique is laborious, and the expression level is unpredictable due to position effects.
She was utterly unpredictable in the positions she took.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com