Sentence examples for unpredictable efficacy from inspiring English sources

Methotrexate, an inexpensive first-line systemic therapy for moderate-to-severe psoriasis, is limited in its use by unpredictable efficacy and toxicity.

In addition to unpredictable efficacy, MTX is associated with a number of severe, dose-dependent side effects, limiting the tolerable dosage level.

Doxycycline has long been used for treatment of Q fever IE [ 41, 42] but its unpredictable efficacy against S.aureus would limit its use in other IE settings.

Methotrexate is a first-line systemic therapy for psoriasis; however, its use is limited by unpredictable efficacy and significant hepatotoxicity and gastrointestinal symptoms.

Compared with allogeneous injectable products, the procedure is time consuming and expensive, with unpredictable efficacy, and often is associated with pronounced swelling of the recipient tissues.

Although 2 hair loss drugs, finasteride and minoxidil, have been approved by the Food and Drug Administration, their efficacies are limited and transient, due to unpredictable efficacies and side effects.

1 It is the second biggest selling drug, with global sales of more than $9bn£5.6bnbn, €6.3bn) a year. 2 A major drawback to its use is its unpredictable clinical efficacy, with insufficient platelet inhibition in about 20% of patients, 3 resulting in a higher incidence of atherothrombotic events.

The use of such generics can be associated with unpredictable safety and efficacy implications [ 42].

An important limitation associated with docetaxel use is the unpredictable interindividual variability in efficacy and toxicity.

Our studies suggest DCA efficacy is unpredictable as a cancer therapy and further studies are necessary to determine the role of this agent in the tumor microenvironment.

This feature was unpredictable from the in vitro efficacy of the two inhibitors towards protein kinase CK2, which instead indicated a superiority of CX-4945.