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23– 26 Third, newly licensed medications, especially biological agents, have enabled the attainment of unprecedented outcomes.
Despite the constraints of cost and the multistep constitution process, their relative safety and early results showing unprecedented outcomes in mRCC warrant continued evaluation of therapeutic vaccines in phase III studies.
Many new treatment options make unprecedented outcomes achievable in rheumatoid arthritis (RA). 1 2 In parallel, insights on the importance of early effective therapy 3 4 and implications of disease activity on function 5 6 and joint damage 6– 8 led to paradigmatic changes in therapeutic approaches, such as frequent evaluations of disease activity to allow for timely changes of therapies.
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"World trade volumes for both goods and services have risen by less than global GDP over the past four years," said economists at UBS. "This is an unprecedented outcome in postwar history.
In an unprecedented outcome, both the shadow chancellor and shadow foreign secretary lost their jobs.
They shake societies to their roots – especially when they are protracted, follow no established script and conclude with an unprecedented outcome.
In spring 2010, Médecins Sans Frontières (MSF) and Nigerian health officials conducting meningitis surveillance in Zamfara State, northwestern Nigeria, recognized an unprecedented outcome of artisanal (subsistence) gold extraction a deadly outbreak of acute childhood lead poisoning (MSF 2012).
Over the past decade, stem cell gene therapy has achieved unprecedented curative outcomes for several genetic disorders.
Recently, a new treatment strategy using chimeric antigen receptor-modified T (CART) cells has shown unprecedented clinical outcomes in hematologic malignancies, and its safety and feasibility in solid tumors was confirmed (Wang et al., 2014; Dai et al., 2015; Wang et al., 2015; Ahmed et al., 2015; Lamers et al., 2013; Feng et al., 2016).
One unprecedented event".
For the past four years, international trade flows have increased more slowly than global GDP – "an outcome unprecedented in postwar history", as analyst Michael Pearce of Capital Economics put it in a recent note.
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