Sentence examples for unprecedented mode from inspiring English sources

However, an unprecedented mode of gene loss was discovered in the lineage spanning R. canadensis and TG rickettsiae, illustrating that gene signatures alone may not well-characterize specific rickettsial groups, but instead the modes of gene loss (and stricter reliance on host resources) may be the defining features [175].

This new structure has revealed a previously unprecedented mode of β-propeller dimerisation involving blade hybridisation.

Due to this unprecedented mode of action ADEPs are not affected by resistance mechanisms compromising antibiotics in therapeutic application and their antibacterial activity against Gram-positive bacteria, including multi-resistant isolates, matches that of marketed antibiotics in vitro as well as in several rodent models of bacterial infection (Brötz-Oesterhelt et al, 2005).

The second NEAT domain of IsdB is structurally similar to other heme binding NEAT domains, and heme-iron is coordinated by a tyrosine residue as predicted; however, we have also shown that Met362 coordinates the heme-iron on the distal side, resulting in an unprecedented mode of heme-iron coordination.

X-ray co-crystallographic studies have revealed an unprecedented kinase binding mode in p38α for representative analogs, 5c and 9d, in which a Leu108/Met109 peptide flip occurs within the p38α hinge region.

A striking biological feature of B. massiliensis is its unprecedented cell division mode which involves initial formation of large polymorphic bodies that fill the cytoplasm of the infected amoeba and subsequently rapidly split into numerous coccoid bacterial cells.

The unprecedented substrate binding mode and cleavage pathway for phenylpyruvate-type structures at the 3-His center of Dke1 suggest that the metal binding motif may contribute to stabilizing the substrate ligand in the correct ionization state.

The thorium III) complex Cp″3Th (Cp″ = C5H3(SiMe3)2-1,3) has been reported to reacts with P4 to give (μ-η1:η1-P4)[Cp″3Th]2, which has an unprecedented cyclo-P4 binding mode.

This " geminal hydrogenation" mode seems unprecedented; it was independently confirmed by the isolation and structural characterization of a ruthenium carbene complex stabilized by secondary inter-ligand interactions.

In complex 1, a 3D architecture with triptycene exhibits an unprecedented μ η2 η2 or μ η2 η2 η1 coordination mode depending on the steric requirements of the network.

This docking mode, which is unprecedented in β-propeller-peptide interactions, is accompanied by the formation of at least five hydrogen bonds between the main chain atoms of the peptide and of the βD-strands of blades five and six and of the βD4-βA5 loop.