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Dr. Sasaki and his colleagues at the Red Cross Hospital watched the unprecedented disease unfold and at last evolved a theory about its nature.
This represents unprecedented disease control and symptom improvement in this disease setting.
If VAMP8 and TNFα are similarly colocalised in hypertrophic chondrocytes, it is tempting to speculate that lysosomal exocytosis in hypertrophied OA chondrocytes might represent a new and unprecedented disease mechanism in osteoarthritic disease.
Moreover, they are faced with enormous and unprecedented disease burdens in tandem with ill-equipped, poorly funded and often dysfunctional health care system in social contexts where the family largely remains the sole source of social security and health insurance for the majority of people faced with disease and risks of premature death.
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"The committee had to balance the risks of treating children with powerful drugs, about which there is limited long-term data, with the risks of not treating children with unprecedented cardiovascular disease risk factors".
Floods are the most frequent and devastating type of natural disaster worldwide, causing unprecedented deaths, diseases, and destruction of property and crops.
CNV analysis has provided an ability to identify disease-causing alterations in an unprecedented number of diseases and phenotypes.
It has led to an epidemic of unprecedented obesity and disease.
It is clear that F. hepatica infection in Britain is likely to expand both geographically and in terms of severity, with regions such as West Wales set to experience unprecedented levels of disease outbreaks.
Furthermore, invaluable and unprecedented insights into disease pathogenesis can be afforded by findings restricted to genetically isolated populations, as exemplified by the elegant metabolic trait study in Greenland [ 6].
The ongoing, unprecedented Ebola virus disease epidemic in Western Africa highlights the urgent need to uncover the biological and ecological factors that underlie the distribution, evolution, and emergence of filoviruses.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com