Our study uncovered unprecedented epigenetic alterations in TAFs from NSCLC patients, including a global impact on gene expression and a selective impact on SMAD3 and other key transcription factors of the TGF-β pathway.
When β1 exceeded β2, however, axonemes with 10 doublets were produced, an alteration unprecedented in natural phylogeny.
In an unprecedented approach, systematic alteration of functional groups or the metal core in C2 to synthesize a series of iridium(iii) complexes (C1 C10) and an organometallic rhenium complex C11 with an imidazolyl modified phenanthroline ligand has indicated the functional groups and their interactions that are responsible for this selective localization.
Whole genome sequencing (WGS) has allowed an unprecedented insight into the alterations underlying cancer.
In the face of unprecedented rates of environmental alterations and species extinctions, conservation biologists, managers, practitioners, and policy makers cannot afford to ignore past, current, and future evolutionary processes.
CNV analysis has provided an ability to identify disease-causing alterations in an unprecedented number of diseases and phenotypes.
Copy number variation (CNV) analysis has had a major impact on the field of medical genetics, providing a mechanism to identify disease-causing genomic alterations in an unprecedented number of diseases and phenotypes.
Small-molecule tyrosine kinase inhibitors (TKI) tailored for oncogenic 'driver' alterations have shown unprecedented success in molecularly selected NSCLC patients harboring epidermal growth factor receptor (EGFR) mutations (EGFR TKI: gefitinib, erlotinib, and afatinib), or anaplastic lymphoma kinase (ALK) fusion gene (ALK TKI: crizotinib, alectinib, ceritinib) [ 3, 4].
We report that an unprecedented level of bacterial genome alteration occurs in B. mallei upon short term passage.
