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In the context of whole human genome resequencing, on the order of a billion short reads are required to accurately resequence an individual genome, and this creates an unprecedented alignment problem of aligning this many reads to the reference human genome on a practical timescale of days.
Today's party divide reflects an unprecedented alignment of many different divides: racial and ethnic, religious, ideological, and geographic.
While 9 of the top 10 films at the domestic box office last year were sequels — an unprecedented alignment — only a handful of such follow-up films made an impression on the Academy.
Typically, these are motivated by a conspicuous success, a development program that was driven by the strength of beautiful molecular data, and the canonical example these days is PCSK9, a target which seems to feature an almost unprecedented alignment of human genetics, biomarker, and animal model data.
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It is also claimed that it's the date when an astronomically unprecedented "galactic alignment" will take place, causing celestial havoc.
"The UK starts from an unprecedented point of alignment with the EU.
This treatment induced a crystallinity increase in the PVA and an unprecedented degree of alignment of the CNTs, leading to a markedly improved energy absorption at low strain [11].
"Efforts are already being employed by brands, retailers, and other organizations to change the industry," MacArthur explains, "and although promising progress is being made, it is often too fragmented or only effective at a small scale...a new textiles economy will demand unprecedented levels of alignment on the case for change, and collaboration.
A modern process like this requires an unprecedented level of sales and marketing alignment.
For now, Japan's independent international leadership is an unprecedented postwar development with potential to shape the entire regional alignment in East Asia.
Photolithographic precision furthermore yields alignment structures that result in mechanically robust, pre-aligned, symmetric microcavity arrays, representing a light-matter interface with unprecedented performance.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com