Your English writing platform
Discover LudwigExact(9)
Conversely, unplanned analyses confer a risk of false positive results.
Throughout the rest of the paper we distinguish between planned and unplanned analyses.
Some changes requested by peer reviewers, however, had a negative impact, such as adding additional unplanned analyses (n=15).
Also, interim analyses should preferably be pre-specified in the trial protocol to minimize bias from unplanned analyses [ 1].
Unplanned analyses suggested that benefit from co-trimoxazole was associated with the proportion of time at risk for which participants were in receipt of trial drug.
Although we conducted several unplanned analyses (not recorded in the original protocol), in common with similar studies, we consider it as an important asset to our data.
Similar(51)
As for many trials and despite methodological concerns, it is very likely that unplanned OS analyses will be reported even after the main analyses have occurred.
It is important to distinguish these overinterpreted, misused, and unplanned subgroup analyses from those prespecified and well-designed subgroup analyses.
These unplanned subgroup analyses are justified to maximize the information that can be obtained from a study and to generate new hypotheses.
In unplanned stratified analyses, selenomethionine favorably affected a change in dysplasia grade among 115 subjects with mild esophageal squamous dysplasia at baseline (P =.02), but not among 123 subjects with moderate esophageal squamous dysplasia at baseline (P = 1.00).
Although it is based on unplanned stratified analyses, this finding is the first report of a possible beneficial effect for any candidate esophageal squamous cell carcinoma chemopreventive agent in a randomized controlled trial.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com