A conservative estimate suggests that there are at least 250 LOF variants per sequenced genome, 100 of them involved in known human diseases, and more than 30 in a homozygous state, which suggests a previously unnoticed level of variation with putative functional consequences in protein coding regions in humans [ 16].
It is a change that has not gone unnoticed by people and machines that monitor levels of pedestrian traffic.
Upon imaging ApoE-GFP with higher laser power, we could detect the remaining phagocytic cell population, expressing low levels of GFP, which went unnoticed using conventional acquisition settings (Fig. 5C).
That, combined with a healthy measure of control at the keyboard and a curiosity about structure, yields levels of detail that can go unnoticed in performances by players who are more heavy-footed and less thoughtful.
This strain has never been associated with bird deaths, which might have resulted from its lower virulence, but low levels of bird deaths might have occurred unnoticed.
The method, used at all levels of American football, remains virtually unchanged and unnoticed after 100 years, taking place beyond the scope of the television camera and the focus of the fans until a precise measurement is needed.
Certain unnoticed rules underlying functional genomes might be found through various kinds and levels of studies.
The presence of differing levels of relatedness among the samples or the existence of unnoticed sub-populations can induce both a loss of power in detecting true associations and generate spurious associations [14], [15], [22], [23].
Both had extensive experience in their work, but their levels of fatigue meant that the problem with the plane went unnoticed.
They theorized that chronic exposure to low levels of these compounds could produce effects in water-dwelling creatures that would accumulate so slowly that they would be "undetectable or unnoticed" until it was too late to reverse them.
