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In the off-line stage, the 1-hop similarities are computed, and an optimized algorithm is designed to reduce the unnecessary accumulation operations on zero similarities.
But Mr Cobden, with that real perception of the facts of commerce which characterised his mind, immediately said, "No, there is no unnecessary accumulation, except in one or two particular markets, as India and China, and in other exceptional cases; we have not more goods on hand than we ought to have".
Further obstacles of the previously applied medium were the nitrogen source NH4Cl, which leads to an unnecessary accumulation of NaCl during pH control with NaOH, and the chelating agent EDTA, which is detrimental to the environment (Oviedo and Rodríguez 2003).
This effect is likely due to the unnecessary accumulation of pterin analog such as 7-substituted pterin, and this problem must be resolved in order to achieve complete conversion of l-tryptophan to 5-HTP.
The intratympanic approach is well accepted by otologists as a rational targeted drug delivery approach because it avoids the unnecessary accumulation of therapeutic agents in non-targeted regions, which has been a prior strategy in the clinic for the treatments of Meniere's disease and sudden sensorineural hearing loss using gentamicin and corticosteroids.
The rapid repression of stress-responsive genes during recovery implies that the action of menin must be tightly controlled to prevent the unnecessary accumulation of heat shock proteins in the absence of stress.
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After initial resuscitation, it is crucial to avoid unnecessary fluid accumulation to limit later requirements for fluid removal.
For many years, researchers have endeavored to deliver therapeutic agents to the tumor region effectively and reduce unnecessary drug accumulation in normal brain and peripheral tissues.
In a cohort of septic patients with AKI, Van Biesen and colleagues [ 8] showed that additional fluid therapy (despite apparent optimal haemodynamics, restoration of intravascular volume and a high rate of diuretic use) not only failed to improve kidney function but also led to unnecessary fluid accumulation and impaired gas exchange.
This would imply that biofilm structures are playing a protective role against salinity that renders unnecessary the intracellular accumulation of K+ as osmoprotectant.
How could virtue be reconciled with the accumulation of unnecessary objects?
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com