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The authors propose that TDG binds its substrate in the unmodified state, and that subsequent to catalysis, sumoylation allows detachment from the product AP-site.
Compared to vegetable oils in their unmodified state, partially-hydrogenated fat is associated with less favorable effects on cardiovascular disease (CVD) risk factors.
The catalytic effect is most pronounced on the surfaces that are less active surfaces in the unmodified state, with enhancement at least an order of magnitude faster kinetics.
They further raise the possibility that the generation and recognition of the unmodified state on histone tails in general might be just as crucial as post-translational modifications of histone for chromatin and transcriptional regulation.
The great age of the chondrites, their primitive chemistry, and the relatively unmodified state of their constituents all suggest that these meteorites retain a record of processes that happened in the solar nebula before and during the phase of planet formation.
The electrochemical stability of Pt deposited on mesoporous carbon, which was either applied in its unmodified state or coated with 20 wt% TiO2, was investigated by cyclic voltammetry in N2 purged 0.5 M sulfuric acid.
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Appropriate signal processing of raw data from an unmodified state-of-the art flow cytometer can yield a fluorescence lifetime estimate based on the delay between the measured fluorescence and scatter response to passing cells (62).
The role of huntingtin in cilia function and the effect of N17 phosphorylation on N17-CRM1-RanGTP interaction led us to examine the cilial localization of endogenous huntingtin in its phosphorylated and unmodified states.
The best two variants identified from lib2 and lib3, H3K27-MetBio2 H3K27-MetBio3Bio3, respectively, were purified in their unmodified states and a portion of the protein was subjected to an in vitro methylation assay.
In their unmodified wild state, red foxes are generally unsuitable as pets.
The unmodified transition state structure was used for a control simulation.
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