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To answer this question, Hen's team genetically modified mice to produce twice as many new brain cells as normal and compared them to unmodified mice.
The mice in the study were genetically altered to respond to the drug, but a company that van Deursen co-founded and a separate group of researchers have already discovered compounds that can kill senescent cells in unmodified mice.
When a new mouse was introduced into their cage, they greeted the new guy much more eagerly than unmodified mice did.
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Autoimmune reactivity against the beta cells could be transferred to unmodified recipient mice but diabetes did not occur.
Despite these marked improvements, we found that histologically-graded OA severity in articular cartilage was unmodified in treated mice.
The in vivo results of the fluorescent image indicated that TGL possessed an effective BBB penetration than that of unmodified ones in mice.
Modification of the H5 HA with the foldon trimerization domain from the T4 fibritin protein also was reported to generate soluble trimeric HA in the recombinant baculovirus system which was more immunogenic than the unmodified protein when mice were vaccinated with recombinant protein with adjuvant [10].
In general, using unmodified rats or mice as animal models is unsuitable for examining diet-induced changes in blood lipids because they do not develop aortic lesions or an atherogenic lipoprotein profile (nHDL-C > HDL-C) similar to human beings [ 25].
They are all used in mouse models unmodified to allow for better conclusions from the mouse models for the situation in the human patient.
NK cell depletion did not significantly affect the rate of decline of unmodified hMSCs in C57Bl mice.
To compare the immunogenicity of the trimeric sHA.GCN4pII and the unmodified sHA, female Balb/c mice (6 8 weeks) were vaccinated subcutaneously (s.c).
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