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The PEX5 LPL and PEX5 LPLvar fusion proteins do not possess the N-terminal signal peptide responsible for targeting LPL to the endoplasmic reticulum before secretion, and are therefore unlikely to be processed in the same manner as full-length LPL.
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In addition to the novel β-secretase substrates it identified, our unbiased proteomic method also revealed other proteins that are elevated by BACE1 overexpression but are unlikely to be directly processed by the protease.
The economy should be able to adjust to such changes over time, but it is unlikely to be a simple process when monetary policy is already very loose and external demand subdued".
Cancer cell lines exhibited a large variation in genome-wide demethylation, which was tissue-specific and thus unlikely to be a stochastic process.
Although I. ricinus ticks infected with B. lusitaniae may be dispersed rapidly over long distances when feeding on highly mobile hosts, such as migratory birds, this is unlikely to be an important process in the effective dispersal of B. lusitaniae.
Hence, the mechanism of inhibition is unlikely to be via these processes but we considered that elucidating the mechanism might shed light on normal CLN3 function.
However, this component appears to reflect the processing of non-symmetrical cue stimuli such as arrows (see Van Velzen and Eimer, 2003 for evidence) and is thus unlikely to be generated by processes that are directly involved in the control of anticipatory attentional shifts.
That means 13,000 cases could be dealt with each year in this centre alone (there are seven others, and normal prisons are also used), saving as much as £30m a year on benefits and other spending for asylum-seekers.Lawyers say that a speedier process is unlikely to be compatible with due process.
13 When the manufacturer of a biosimilar establishes its own manufacturing process, this process is unlikely to be 100% the same as the process of the reference biopharmaceutical.
As with steel or aluminium, it is unlikely to be dislodged from industrial processes any time soon, so some form of carbon mitigation is essential.
That having been said, sorption is unlikely to be a significant removal process for the analytes that were consistently detected.
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