We introduced a R588A/E592A mutation in JAK2 V617F and observed no significant decrease in STAT5 transcriptional activity relative to the nonmutated protein, unless F595A was additionally introduced (Figure S1).
To match from mean or median back to classes, a binning is needed, unless we want to introduce novel classes "in between" (consider the example of two raters judging "0" and two "1": by that we obtain a new class "0.5").
First and foremost is the fact that the systems and networks one infers often have so many units/nodes that the problem is not well-posed, for any mathematical model, due to lack of data [6], [7] (unless one introduces further constraints, such as sparseness).
In mathematics, "unless children are introduced to that stock of knowledge, unless they know how to use numbers with confidence, unless multiplication, long division, become automatic processes, they won't be able to use mathematics creatively … to make the discoveries which are going to make our lives better in the future".
"Unless you introduce it as an individual right, the take-up won't be that high," Javornik says.
I've never been to any day there, truth be told, and unless they introduce a Scruffy People Who Believe Horse Racing to Be Deeply Cruel Day and pay me to attend I can't see that changing.
"The problem with means-testing is that, as we've seen in Bangladesh, arbitrary decisions are being made about who qualifies and who doesn't, which creates divisions in communities," says Pearson. "Unless you introduce a universal scheme you're never going to get away from the difficulties faced by helping some people and not others".
Unless I introduce myself and mention what I do in fashion, this is almost always the case.
Unless we take radical action to introduce permanent structural change the future for the airline is bleak.
Whatever share of media ends up being downloaded, Amazon will miss out unless it introduces its own service.
