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Open-label metformin was also continued in participants initially randomized to receive metformin (850 mg twice daily as tolerated) during the DPPOS, unless discontinued for the development of diabetes requiring management outside of the protocol, or for reasons of safety and/or tolerability.
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The EPHT Trial Steering Committee had its meeting in September 2002 and unanimously decided to continue the trial unless WISDOM discontinued for ethical reasons.
Subjects who received ≥4 doses of study drug (unless they discontinued for safety reasons) and had ≥2 exercise challenge tests (baseline and post-therapy) were considered evaluable.
Patients with adequate pain relief and no intolerable AEs (responders) were assumed to enter the maintenance treatment phase, where they remained unless they discontinued therapy or ceased to have sufficient pain relief.
Patients with a recently implanted coronary drug-eluting stent (DES) who need urgent surgery are at increased risk of surgical bleeding unless clopidogrel is discontinued beforehand, but clopidogrel discontinuation has been associated with a high rate of adverse events due to stent thrombosis.
But its high cost has raised concerns that it may be discontinued unless the EU agrees to contribute funding.
This data pleads against reintroduction of CQ in places where resistant allele frequency has dropped to a very low level after CQ use has been discontinued, unless drastic measures are put in place to prevent selection and spreading of mutants during the post-treatment period.
Postoperative antibiotic administration was discontinued unless evidence of infection persisted.
In 3 studies, antibiotics were discontinued unless they were deemed "essential to the patient's clinical treatment" [ 21, 22].
For grade 4 non-haematological toxicity RT was discontinued unless toxicity settled to grade 0 1 within 2 weeks when it could be continued and chemotherapy was discontinued permanently.
All patients also received oral calcium (700 mg) and vitamin D3 (400 IU) supplements unless they had discontinued calcium supplements in the TOP study.
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