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Transmission-blocking drugs have only limited effects unless administered with a prophylactic under very high coverage.
The rapidity of its spread may result in fatality as antibiotic therapy can be ineffective unless administered during early stages of the disease.
Recent studies with animal models indicate that inhaled mitogens are strikingly effective in inducing pulmonary inflammation, whereas inhaled antigens (lacking mitogenic activity) produce little if any parenchymal injury in immunized recipients, unless administered in conjunction with a mitogen.
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"Even something as effective as penicillin can fail unless it is administered properly," Bateman says.
Intravenous contrast medium (CM) should be administered, unless contraindicated.
Intravenous contrast is also routinely administered unless contraindicated, with imaging performed in the portal venous phase.
No prophylactic premedication was administered, unless indicated by previous infusion reaction experience in an individual patient.
Chemotherapy was administered unless a criterion for study discontinuation was met.
The treatment regimen was repeated every 4 weeks and at least two cycles were administered unless disease progression or an unacceptable toxicity occurred.
In these cases, pharmacological prophylaxis (indomethacin (75 mg daily for four days) followed by naproxen (500 mg twice daily for 30 days)) should be administered, unless contraindicated.
The next cycle was not administered unless the granulocyte number was ≥1,500/mm³, platelet number ≥100,000/mm³, and all non-hematological toxicities resolved to grade ≤1.
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