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We found that a putative lipid-binding protein Ppa-OBI-1 mediates both beetle pheromone attraction as well as a previously unknown role of the beetle pheromone to regulate P. pacificus development.
Taken together, we have demonstrated the importance of the HEC-SPT module in the developing gynoecium and provide evidence for a yet unknown role of the HEC genes during carpel fusion.
In the present work, we have provided important insight into the mechanisms by which Myc represses differentiation genes to promote pluripotency: a previously unknown role of the Myc/Miz-1 complex in repression of differentiation-related genes in human ES cells.
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Mutants of Thr201 illustrated the importance of the methyl group in aiding the formation of the Isopentenyl pyrophosphate (IPP) binding site, while Tyr204 mutations revealed the unknown role of this residue in both catalysis and IPP binding.
In conclusion we have identified new features of FPPS inhibition by N-BPs and revealed unknown roles of the active site residues in catalysis and substrate binding.
It also brings out the hitherto unknown role of directionality of the grid in controlling the accuracy of the numerical solution of multidimensional PBEs.
Future studies should aim to elucidate the as yet unknown role of neuroimaging in the diagnoses and prognostication of Legionellosis, as well as the interaction between Legionella infection and HIV.
These data point to a so far unknown role of FAP in the attachment of SF to cartilage, promoting proteoglycan loss and subsequently cartilage degradation in chronic inflammatory arthritis.
Such analysis can also provide a powerful approach for elucidating the unknown role of a given gene, based on the pathways or processes in which the other genes in the same network are involved.
Several groups have recently published data demonstrating this critical, and previously unknown, role of hypoxia in maintaining the stem-like fraction of cancer cells (Jogi et al, 2002; Heddleston et al, 2009; McCord et al, 2009).
Furthermore, our results might represent a missing link between the yet unknown role of MC-1R in cutaneous biology and the influence of MC-1R in skin cancer development.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com