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We also collected 89 healthy Texel sheep with unknown relatedness resulting in a total of 403 samples.
Testing a population sample of 89 healthy Texels which had unknown relatedness revealed none carried the homozygous C/C genotype, while four were presumed carriers with the G/C genotype.
In cases, where genealogical information is not available we now know that IBD is an alternative to account for unknown relatedness.
In order to avoid analysis of close relatives, unknown relatedness was measured between all pairs of individuals within each population using PLINK's (v1.07) Identity-by-Descent estimation, PI_Hat.
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Probably for this reason our RAPD analysis resulted in the clustering of isolates previously known to belong to a certain phylogenetic species (Pb01-like, S1 and/or PS2), which could be a reference for the characterization of those of unknown genetic relatedness (Table 3, see isolates Ed01, 1578 and utero).
– unknown unknowns.
A comparatively new form of forensic DNA testing uses crime-scene samples to identify unknown suspects through genetic relatedness profiling (Bieber et al. 2006; Butler 2011; Gershaw et al. 2011).
We considered the evidence for detecting unknown familial relationships, or cryptic relatedness, among individual CD-1 mice by assessing departures from Hardy-Weinberg equilibrium (HWE).
These data are estimated to derive from at least 1800 genomic species based on sequence relatedness, including 148 previously unknown bacterial phylotypes.
No information is available on how many or which F0 parent pairs were used to produce these F1 animals and, consequently, relatedness between individuals is unknown.
Cryptic relatedness, i.e., unknown genetic relationships between individuals in a sample, can also confound the association analysis due to nonindependence and larger than expected phenotypic variance (Voight and Pritchard 2005; Cheng et al. 2010).
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